Slash's guitar work on Estranged — particularly the extended closing solo over orchestral strings and a dolphin-filled music video — represents his most ambitious and emotionally expansive performance. The solo stretches over several minutes and passes through multiple distinct emotional phases, from anguished pleading to transcendent release. Many guitarists consider it Slash's finest recorded work, surpassing even November Rain.

Reference:

Wikipedia: Estranged

https://en.wikipedia.org/wiki/Estranged_(song)