
Innate immunity (non-specific, fast):
Physical barriers: skin, mucus, cilia
Phagocytes: neutrophils, macrophages, dendritic cells
Natural killer cells: destroy virus-infected and cancer cells
Complement system: proteins that lyse pathogens
Inflammation: redness, heat, swelling, pain
Adaptive immunity (specific, slow, memory):
B cells — humoral immunity; produce antibodies (immunoglobulins)
T cells — cell-mediated immunity
Helper T cells (CD4⁺) — activate B cells and cytotoxic T cells
Cytotoxic T cells (CD8⁺) — kill infected cells directly
Regulatory T cells — suppress immune response
Memory cells — enable faster response upon re-exposure
MHC (Major Histocompatibility Complex):
MHC I — on all nucleated cells; presents intracellular antigens to CD8⁺ T cells
MHC II — on antigen-presenting cells; presents extracellular antigens to CD4⁺ T cells
HIV destroys CD4⁺ Helper T cells → immune collapse → AIDS
Reference:
TaskLoco™ — The Sticky Note GOAT