
CNS (Central Nervous System) — brain and spinal cord
PNS (Peripheral Nervous System) — all other nerves
PNS → Somatic (voluntary) and Autonomic (involuntary)
Autonomic → Sympathetic (fight-or-flight) and Parasympathetic (rest-and-digest)
Neuron anatomy:
Dendrites receive signals → Cell body integrates → Axon transmits → Synaptic terminal releases neurotransmitters
Action potential:
Resting potential: −70 mV
Depolarization: Na⁺ rushes in through voltage-gated channels → membrane reaches +30 mV
Repolarization: K⁺ rushes out → returns toward resting potential
Hyperpolarization: briefly more negative than resting
Refractory period: cannot fire again immediately
Synaptic transmission:
Action potential → Ca²⁺ influx → vesicle fusion → neurotransmitter release → binds postsynaptic receptor → excitatory (EPSP) or inhibitory (IPSP)
Key neurotransmitters: Acetylcholine, Dopamine, Serotonin, GABA (inhibitory), Glutamate (excitatory), Norepinephrine
Reference:
TaskLoco™ — The Sticky Note GOAT